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doi:10.1523/JNEUROSCI.22-15-06480.2002 pmid:12151527 Kirkland R, Saavedra GM, Cummings BS, Franklin JL (2010) Bax regulates production of superoxide in both apoptotic and nonapoptotic neurons: role of caspases

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Nevertheless, the aberrant activation of c-Met and downstream signaling pathways through overexpression of HGF or c-Met, gene amplification, mutational activation of c-Met, down-regulation of Met-targeted miRNA, binding to other ligands, autocrine signaling or abnormally high HGF levels initiates and drives tumorigenesis and promotes tumor growth, invasion, metastasis, and angiogenesis in HCC