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Inhibition of ALA synthesis in young mice replicates the aging phenotype of small intestines in old mice After observing a decrease in ALA synthesis in human and mouse small intestines upon aging, we next assessed whether suppressing ALA synthesis in young mice could replicate the aging-related changes observed in the small intestines

Of note, LCA supplementation alleviated pacing-induced AF susceptibility in the obese mice

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We further found that maternal high-fat diet downregulated mRNA and protein expressions of carnitine palmitoyltransferase 2 (CPT2), a key enzyme in FAO, by suppressing the AMPK/Sirt1/PGC1 signaling pathway in the placenta