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Finally, the amino acid cysteine (Cys) at position twenty-seven is replaced with a modified amino acid called N-methylglycine (Sar)

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DOI: 10.4239/wjd.v5.i6.809 47

This results in a decrease in mitochondrial transcription factor TFAM and impaired mitochondrial function, which ultimately leads to increased vulnerability to oxidative stress and neuronal deterioration (Sharma A

Zhao Z., Shan X., Ding J., et al., Boosting RNA Nanotherapeutics With VATPase Activating NonInflammatory Lipid Nanoparticles to Treat Chronic Lung Injury, Nature Communications 16 (2025): 6477