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KNOCK-IN MUTATION Introduction of a transgene into a precise location in the genome, rather than random integration

Conclusion The GST gene family was subject to a huge genetic expansion in terrestrial plants, with an average number of GSTs around 58 but also in some particular fungi (up to 45 isoforms) ( According to their stress-inducible expression, it is documented that many GSTFs and GSTUs have functions connected to secondary metabolism, as exemplified by their implication in the vacuolar sequestration of anthocyanin, in the biosynthesis of camalexin, and/or in the binding of biosynthesis intermediates (porphyrin derivatives) or cellular by-products (oxylipins)

Mdicament rvis par Vanessa Atan, Infirmire Autorise, BSc, BA

What also supports this therapeutic idea is that balanced 2 -AR agonists run the risk of therapeutic tolerance or loss of response with prolonged treatment, as data suggests that desensitization and downregulation of 2 -Ars occurs downstream of -Arr binding (Gagnon et al., 1998)