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3,4 Patients with AD exhibit a substantial accumulation of amyloid- (A) plaques and neurofibrillary tangles (NFTs) within their brains, accompanied by a cascade of pathological processes such as neuroinflammation, synaptic dysfunction, mitochondrial and bioenergetic disturbances, as well as vascular abnormalities

Plant Physiol 113:93102 Mieyal JJ, Chock PB (2012) Posttranslational modification of cysteine in redox signaling and oxidative stress: focus on S-glutathionylation

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NRF2 and KEAP1 somatic mutations have been shown to correlate with poor clinical outcome in several cancers such as renal cell carcinoma and pancreatic cancer (Jaramillo and Zhang, 2013

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