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Description
Nrf2 works in combination with small avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF) proteins: together they recognize and bind antioxidant response elements (ARE) in promoters of antioxidant enzyme genes (phase 2 enzymes such as glutathione S-Transferase (GST), UDP-glucorosyl transferase and superoxide dismutase (SOD), GSH peroxidase (GPx) and catalase (CAT), sulfiredoxin 1 and Thioredoxin reductase 1 [16,17,18,19]
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doi: 99
Sinauer Associates
The profibrogenic potential of activated HSCs is due to their capacity to synthesize fibrotic matrix proteins and components that inhibit fibrosis degradation
