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PMID 17940090

Finerenone and Clinical Outcomes in CKD and Type 2 Diabetes by Frailty Index: FIDELITY Post Hoc Analysis

Free radicals are unstable molecules that can damage cellular structures like DNA and proteins

These modifications result from direct ROS attack on amino acids (proline, arginine, lysine, threonine) or indirectly via reactive aldehydes from lipid peroxidation (MDA, 4-hydroxynonenal), or through reactions with reducing sugars and advanced glycation end-products (Pinzaru et al., 2023)

From the oxidative killing defect seen in CGD phagocytic cells, there is no doubt that ROS play an important role, but the actual mechanisms by which ROS damage pathogenic invaders in the phagosome are poorly understood [100]