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Description
These are two related but separate endeavors

Newsome PN, Buchholtz K, Cusi K, et al

What this means practically: if you have an MTHFR variant AND estrogen dominance symptoms, the 3-Supplement Protocol supports the COMT methylation pathway specifically because methylfolate feeds the chain that produces SAMe, and SAMe is what COMT needs to clear estrogen metabolites

As always follow the money as thats where the answer lies

Molecular Characteristics: It has a molecular formula of CHNO and a molecular weight of approximately 848.8 g/mol