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However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2
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Research demonstrates TB-500 reduces inflammatory markers including IL-6 and TNF-alpha while releasing the anti-inflammatory fragment acetyl-SDKP, creating conditions that favor repair over chronic inflammation
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