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This study suggests that DSIP may have geroprotective and anti-cancer properties, making it a potential peptide of interest for longevity research

Macrophage-derived legumain promotes pulmonary hypertension by activating the MMP (Matrix metalloproteinase)-2/TGF (Transforming growth factor)-1 signaling

Several adipokines/cytokines such as leptin, resistin, retinol-binding protein 4 (RBP4), angiopoietin-like protein 2, IL-6 and MCP-1 promote the atherosclerotic process by inducing inflammation, endothelial dysfunction and insulin resistance (139)

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Wyckelsma VL, Levinger I, McKenna MJ, Formosa LE, Ryan MT, Petersen AC et al (2017) Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training: high-intensity training in elderly humans