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This is coupled with an exaggerated inflammatory response driven by the intestinal microbiota, leading to extensive infiltration of various immune cells, including T cells, B cells, dendritic cells (DCs), macrophages, and neutrophils, into the lamina propria

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HCV-2 achieved 100% and 92% of SVR12 in those without and with cirrhosis, respectively, while the response rates were lower and at 83% in both groups of HCV-3 patients.[87] Additional studies evaluated the safety and efficacy of sofosbuvir and RBV in various IFN-based and IFN-free regimens in HCV-1, HCV-2 and HCV-3 patients, but in small cohorts