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Venography Venography was performed in rats with a ligation of the superior sagittal sinus at 15 min post-ligation, using a C-VISION PLUS fluoroscopy unit (Shimadzu, Chiyoda, Tokyo, Japan) [20,26,27]

The pharmacokinetic profile does not change with repeated administration

these abnormalities may progress, remain unchanged, or be transient with continued therapy

A community-based study of elderly persons similarly showed that serum indices of relative vitamin B12 levels were associated with increased risk of progressive brain atrophy over 5 years (262)

The care of the animals was in accordance with the standard operating procedures of the facility for pharmacological animals and the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (ETS 123)