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Genotoxicity evaluation encompassed an Ames mutagenicity evaluation, a chromosomal aberration assay in Chinese hamster ovary (CHO) cells, and a bone micronucleus assay incorporated within a 4-week toxicology study in murine models

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This observed relation between low vitamin B-12 concentrations in pregnancy and child insulin resistance was also supported by data from Nepal, but supplementation of pregnant women with vitamin B-12containing micronutrients was not found to affect child HOMA-IR (40)