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These processes do not only depend on intracellular dynamics of hepatocytes, but are in part regulated by intercellular signaling between hepatocytes and immune cells such as the livers resident Kupffer cells (KCs) and recruited monocyte-derived macrophages (ms) 14

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Recent studies have shown that lipophilic statins may have certain therapeutic effects on neurodegenerative diseases, potentially exerting their benefits through various mechanisms such as anti-inflammatory and antioxidant actions

Dephosphorylation and activation of MTHFR may also serve as a cellular response to hyperhomocysteinemia (HHcy), ensuring sufficient concentrations of active folate for the remethylation of Hcy and the elimination of toxic effects caused by this amino acid [23]