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In an early work by Rice and Russo-Menna (1998) [76], GSH levels of glutathione in neurons and glia were reported to be 2.5 nM and 3.8 mM, respectively
& Jia, J
This suggests that the cells rely on GPX4 to resist oxidative stress, and this could potentially increase their sensitivity to RSL3, a ferroptosis inducer that targets GPX4
Alpha-Lipoic Acid for Antioxidant Synergy Alpha-lipoic acid (ALA) functions as both a direct antioxidant and a support for glutathione recycling
[Abstract]2026 Jan 23;22(1):e1012013
