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Description
Fleisher DR, Matar M
Recent studies suggest that PQQ activates SIRT1 and SIRT3 genes and increases NAD + activity in the human hepatocyte cell line HepG2 41 , induces deacetylation of PGC-1 and enhancement of mitochondrial activity in NIH/3T3 cells after treatment with a SIRT1 selective inhibitor 76 , and protects skeletal muscles from denervation-induced atrophy by activating PGC-1 and improving the energy metabolic profile in C57BL6/J mice 77
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10.1001/jama.2020.14819 32 GaraffaG.TrostL
