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GHK-Cu upregulates collagen I and III synthesis, inhibits matrix metalloproteinases (MMP-1, MMP-2, MMP-9), activates TGF-beta signaling, and promotes angiogenesis via VEGF pathways

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Studied in preclinical models of tissue regeneration, angiogenesis, inflammatory signaling and gastrointestinal integrity

CagriSema: GI adverse events in 72.5% of patients

BPC 157 counteracted increased P wave amplitude, tachycardia and ST-elevation, i.e ., right heart failure from acute thrombotic coronary occlusion