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Abbreviations IL-23: Interleukin 23 TNF- : Tumor necrosis factor-alpha HELP: Half-life extension partner 3dHSA: Third domain of human serum albumin HcAb: Heavy chain antibody VHH: Variable heavy domain of HcAb EC50: Half-maximal effective concentration References Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D

B12 raised mRNA levels of IL6 and IL17A in both MOD and SEV, matching them to CTRL at endpoint A

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