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In the context of diabetic myocardium with I/R injury, apelin overexpression exerts cardioprotective effects via suppressing oxidative stress and apoptosis through the Phosphoinositide 3-kinase (PI3K) and p38-MAPK signaling pathways in rats [158]

doi: 10.1046/j.1365-2362.2000.00736.x

Study design and animal grouping BALB/c albino male mice were used as the suitable animal strain for the experiment

However, it did not prevent neuronal loss in the hippocampus, suggesting that while antioxidants can improve cognition, they may not halt irreversible neuronal degeneration

N-Acetyl cysteine is associated with dopaminergic improvement in Parkinsons disease