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Milk thistle is cultivated as a medicinal plant in parts of India such as Uttar Pradesh, Punjab, Haryana, Rajasthan, Gujarat, Madhya Pradesh, and Tamil Nadu, where its seeds are valued for their liver-supporting compound, silymarin

Interestingly, oxidative stress-mediated S-glutathionylation of PFKFB-3 decreases its catalytic activity in cancer cells, redirecting the glycolytic flux to the PPP (Seo and Lee, 2014)

Ossenkoppele G, Montesinos P

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.de Wit E, van Doremalen N, Falzarano D, Munster VJ

While these are not systemic therapies, they represent a growing use case within anti-aging and facial aesthetics