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Vitamin B12 is an important cofactor for many enzymatic reactions in mammals that are required for normal cell growth, reproduction, and function

This accumulation results in mitochondrial dysfunction, impaired synaptic structure and function, and an imbalance of protein homeostasis

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Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

His last words to them were, I will meet you when you cross the bar. As per an article in The New York Times , Pearson left his daughters on their vessel when he climbed the rope ladder into the pilot boat, an act he had done for so many years