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Small observational studies have reported modest weight loss, but these typically lack adequate controls for dietary modification, exercise, and placebo effects
81 VM is critically regulated by several signaling pathways associated with embryonic/stem cell (Nodal and Notch4), vascular (VE-cadherin, VEGFR1, EphA2) and hypoxia-related HIF and Twist1 (Qiao et al

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Although tirzepatide has no established direct mechanism for causing insomnia, several indirect pathways may explain why some patients experience sleep disturbances during treatment

Strengths and limitations of this case Strengths 1
