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Additionally, optimizing HDL functionality, increasing nitric oxide production, and inhibiting the oxidation of LDL cholesterol are a number of other beneficial effects found in numerous studies with omega-3 supplementation, also in agreement with the adapted physiology found in fish and marine mammals that provide them with an added resistance to atherosclerosis, thus making omega-3-based supplements ideal for the prevention and treatment of cardiovascular diseases [41, 50]

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