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Asparaginases, enzymes that deplete circulating glutamine and asparagine, are approved for the treatment of acute lymphoblastic leukemia, but are also under investigation in AML, with promising results

A total of 3 or 5 days later, cells were fixed in 4% PFA for 45 min and then stained with DAPI, as described above

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An Italian multicenter study showed that the mean age of patients was 62.5 and 48 years for type 1 and type 2 AIP, respectively, and the proportion of cases that were male was 66.9 and 54.2%, respectively [25]