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Lions mane has growing interest and some RCT evidence, but its still early and not definitive

[DOI] [PubMed] [Google Scholar] 27.Tieu K

The role of peroxisome proliferator-activated receptor coactivator-1 in the pathogenesis of fructose-induced insulin resistance

Common side effects for both include mild injection-site reactions, transient water retention, and occasionally a 'flushing' sensation immediately after injection

Raza Naqvi, S