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Insulin resistance can also be promoted by several signaling pathways activated by ROS, such as NF-B [22,23]
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10.1196/annals.1454.017 58 SmithJ
Defective pyruvate dehydrogenase complex deficiency with reduced acetyl-CoA production results in decreased production of reducing equivalents in the form of NADH and, thus, decreased ATP through the mitochondrial respiratory chain and, consequently, an energy deficit
