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Recent advances in viral vector-based gene therapy have shown promise in preclinical models, with clinical trials underway to assess safety and efficacy in FD patients (77)
During the GPx cycle, ebselen selenol is oxidized to ebselen selenenic acid by hydroperoxides which is then recycled back to ebselen selenol by consuming thiols (Fig
Polyphenols have been shown to enhance tight junction integrity, increase mucus secretion, and decrease intestinal barrier permeability, thereby generally improving the intestinal defense mechanism [156,160]
Radiotherapy can increase the expression of ACSL4, thereby enhancing ferroptosis in glioma cells
