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Certain medications may make it harder for your body to absorb B-12, including: Acid reflux and peptic ulcer disease medications, including: famotidine (Pepcid AC) lansoprazole (Prevacid) omeprazole (Prilosec) Metformin (Glucophage, Glumetza), a common type 2 diabetes treatment chloramphenicol, an antibiotic Very low levels of vitamin B-12 can result in serious complications, including anemia

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For B12 to be absorbed, it requires a protein called intrinsic factor (IF)