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These findings collectively suggest a plausible mechanism whereby GSDMD-N could be transferred indirectlypotentially via extracellular vesiclesfrom supporting cells to hair cell membrane and directly inducing pyroptosis

Redoxosomes contain redox proteins that are involved in transmitting ROS signals from interior to outer membranes, and they regulate ROS as a secondary messenger (Oakley et al., 2009)

Anti-interference study NaCl, KCl, CaCl 2 , Na 2 SO 4 , NaNO 3 and NaBr were employed to study the interference of anions, such as Na + , K + , Ca 2+ Cl - , SO 4 2- , NO 3 - and Br - , and the concentration of each anion was set at 10 mM

This work was supported by the NSERC RGPIN-2023-05099 (R.W.)

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