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Some research from Germany has shown that an even higher threshold (over 500 pg/mL) is necessary in early-to-mid pregnancy to maintain vitamin B12 levels throughout pregnancy, lactation, and to support an infants vitamin B12 status (via breast milk) through 6 months of age

In cases of suspected cobalt hypersensitivity, an intradermal test dose should be administered

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How often a person will require shots depends on what is causing their B12 deficiency