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Results Glutathione depletion vulnerability Glutathione is not only the dominant coordinating ligand for cytosolic ferrous iron 22 but is also the substrate used by glutathione peroxidase-4 (GPX4) to clear the lipid peroxides that induce ferroptotic cell death 2527

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87 MadoreC.LeyrolleQ.LacabanneC.Benmamar-BadelA.JoffreC.NadjarA.et al (2016)

, Reference Freed2017

NAC elevates intracellular GSH, suppresses H 2 O 2 accumulation, and blocks the NLRP3-CASP1-GSDMD pathway in vitro and in vivo 59-61