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intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies

Missing occasional doses wont derail progress, but consistent daily administration produces best results

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Long-Term Safety Considerations While 24-week human trials provide reassurance about short-to-medium term safety, very long-term data (multi-year continuous use) is limited

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