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"Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous"

Taken together, these findings highlight the TCA cycle as a pivotal metabolic node for disrupting genome stability

doi: 10.1016/j.abd.2020.09.004

This, in combination with well-developed compassionate use programs and the dissemination of accessible information, would foster a better understanding of the landscape of IGF-I deficiency disorders internationally, and contribute towards improved diagnosis, access to treatment, and burden of care for patients worldwide

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