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In humans, COX consists of two core subunits, COX1 and COX2, which bind Cu at the conserved Cu B and Cu A sites, respectively

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AEP: auditory evoked potential EEG: electroencephalograph GSH: glutathione NAC: N -acetyl-cysteine MMN: mismatch negativity NMDA: N -methyl-D-aspartate References Aydin S, Ozaras R, Uzun H, Belce A, Uslu E, Tahan V et al (2002)

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The other 16 studies were excluded because the animals were not rats ( n = 4), the studies involved cell culture and tissues ( n = 6), the studies did not assess antioxidant markers ( n = 5), and one text was not available in its entirety (Figure 2) [12,13,14,15,16,17,18,19,20,21]