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Interestingly, DHBT-1 and its electrophilic metabolites are potent inhibitors of KGDHC (Shen et al., 2000) and PDHC activity (Li and Dryhurst, 2001) in disrupted rat brain mitochondria, apparently via covalent modification of crucial cysteine residues

Toxicity: Not for use in humans or animals

doi: 10.1073/pnas.0501282102

FASEB J 29(11):457988

Individual response can vary, and many practitioners recommend starting conservatively and adjusting based on observed results
