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Previous RCTs in critical care/population settings and methodological issues In 2014, the VITDAL study showed no benefit of vitamin D supplementation on the primary endpoint in 480 mixed critically ill patients with vitamin D deficiency (defined as 25OHD 1,000 patients), the VIOLET study (Table 2

Its method of action involves binding to ghrelin receptors, specifically the Growth Hormone Secretagogue Receptor (GHS-R1a), located in the hypothalamus and pituitary gland

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