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Description
This routes biologics and peptides directly into the CNS, bypassing first-pass hepatic metabolism and avoiding the highly selective BBB entirely
Physiol 302 , R274282, (2012)
[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Li D, Li D, Wang Z, Li J, Shahzad KA, Wang Y, Tan F
76 Occludin is composed of four transmembrane domains
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