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Thus, survival and normal functionality of cells are critically dependent on oxygen delivery performed by the heme-containing hemoglobin protein, which is the most abundant protein in erythrocytes [43]

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This strategy can enhance immunogenicity without an adjuvant and promotes a robust cytotoxic T cell response to eliminate virus-infected cells

Specifically, 4-HNE has been shown to induce the nuclear localization of Nrf2, a transcription factor that regulates the expression of antioxidant proteins like heme oxygenase-1 (HO-1)