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It is naturally available in animal products, but deficiencies can occur due to dietary restrictions, malabsorption issues, or certain health conditions

The use of nucleic acids or nucleic acid analogues that may alter genome sequences and/ or alter gene expression by any mechanism

Regarding the mechanism by which NNMT regulates energy expenditure, they proposed that SAM and NAD + are involved because SAM and NAD + are modulated in the process of NA methylation by NNMT [11]