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numerous trials have confirmed its effectiveness in alleviating IRI in the heart, kidney, intestine and liver (154156)
The researchers did not observe any serious adverse effects throughout the study
For instance, Esworthy et al
(4) This alteration might support IGF1 receptor activation, leading to a more robust anabolic response in laboratory settings
While numerous compounds have demonstrated efficacy in vitro and in murine models, no phase I or II trials directly targeting NRF2 have been conducted in HCC patients, raising concerns about their applicability in clinical practice
