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Usually, B12 injections may be given daily on the first start of treatment
SAM acts an allosteric regulator of enzymatic activity of the TS1 ( MTO2 role in stem cell maintenance is specific for these cells, how it may interact with TS2 activity, where exactly in the RAM MTO2 expression is critical are all open questions
Trends Microbiol 11(10):479487
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Clin Cancer Res 23(15):4146-4154, 2017
