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Nevertheless, chemotherapy continues to be the main treatment option against PDAC due to the absence of effective alternative approaches

SFN reduces the expression of adipogenic factors such as PPAR and CCAAT/enhancer-binding protein (C/EBP), which inhibits adipocyte formation and fat accumulation

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Thus, the identification of glial subsets involved in disease initiation, progression, and maintenance remains a critical goal in their molecular characterization

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