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The beyond use date for an opened or entered (e.g., needle punctured) multiple-dose container with antimicrobial preservatives is 28 days, unless otherwise specified by the manufacturer

Watch for worsening pain and spreading redness beyond the immediate area after 48 to 72 hours, fever, a hard warm lump, or systemic allergic symptoms such as hives, facial swelling, throat tightness, or breathing difficulty

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