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Family history of pernicious anemia or autoimmune disorders increases the risk of developing antibodies

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In conclusion, treatment with 0.8 mg/kg of adalimumab for 16 weeks in children and adolescents with severe plaque psoriasis provided significant improvements in PASI75 and a non-significant increase in patients who achieved clear or minimal PGA compared with methotrexate

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Because an analog is not identical to the naturally occurring peptide, early-phase trials primarily assess safety rather than proving long-term effectiveness