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2018;34(5):e3001

[DOI] [PubMed] [Google Scholar] 118

Genetic polymorphisms in genes coding for enzymes, receptors, and transporters related to opioid disposition (pharmacokinetics) and pharmacology (pharmacodynamics) are well documented.169 Examples include pharmacogenetics of various enzymes, such as cytochrome P450s and uridine diphosphoglucuronosyltransferases, opioid receptors, and the ABC family of transporters

Together, ascorbate involves many biologic and metabolic processes so its mechanism remains to be clarified and perhaps it should be mentioned that this vitamin is not well known

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