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There are a number of studies showing that exposure of VSMC to high glucose conditions results in oxidative stress and subsequent cell proliferation

In short, it's a protein that is normally digested once it reaches the stomach

Int J Drug Dev & Res 8:021-027 Alzheimers disease (AD) patients are presently without adequate treatment thus new therapeutic approaches are needed to slow and hopefully reverse disease progression

Zhang et al., Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer