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For instance, in the case of advanced/metastatic non-small cell lung cancer (NSCLC) with METex14, GEOMETRY mono-1, a multicenter, open-label, multicohort phase 2 trial, demonstrated that capmatinib was highly effective against tumors in patients with advanced or metastatic NSCLC at stages IIIB and IV, particularly those with METex14 or MET amplification, especially in settings without prior treatment [27]

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On a normal chow diet, HSL-null mice had body weights similar to wild-type mice (47), and adipocyte size was reportedly either similar or slightly larger (94)a finding that is consistent with a role for HSL in adipocyte FA mobilization