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4 GST inhibitors and prodrugs are crucial agents that can help reverse multidrug resistance in tumors and increase the therapeutic index of anticancer drugs, which collectively decreases the physical and economic burden of cancer patients

Therefore, we inferred that GPX3-mediated autophagy may be an upstream mechanism that could adjust cellular OS and iron homeostasis during ferroptosis

Interestingly, within the GSTF family, GSTF5 is only highly expressed at the two first stages of siliques/seeds (siliques bearing developing seeds), a specificity that is also found for GSTF12 , albeit the transcript abundance also peaks during DLS