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The mAbs identified in this study, while a relatively small number and from one representative animal, appear to provide a reasonable representation of the antibodies present in SpFN-immunized macaque serum, and defined the RBD-specific antibody molecular recognition of neutralization and cross-recognition of sarbecoviruses elicited by SpFN vaccination

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Using a similar model, they pretreated transgenic mice expressing human ACE2, generated by Lin Gan, PhD, director of MCGs Transgenic & Genome Editing Core, with the spike protein and then infected them with Streptococcus pneumoniae

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