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Description
While direct evidence that specific HIV-1 proteins or transcripts drive microglial kynurenine pathway activation remains limited, acknowledging this axis improves completeness and indicates testable crosstalk with the hierarchy above

Overnight digestion of the samples was performed by adding 0.5 g of trypsin to each sample

Thus, dysfunctions in complexes I, III, and IV are more likely to occur under oxidative stress

It is worth mentioning that chloroacetamide has an overall higher reactivity against the proteome than acrylamide warhead, indicating a correlation between warhead intrinsic reactivity and proteome hit rate

However, these side effects are typically rare and transient
